CALL FOR PAPERS Mitochondrial Dynamics and Oxidative Stress in Disease Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells
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چکیده
Tuyet Thi Nguyen,* Xianglan Quan,* Kyu-Hee Hwang, Shanhua Xu, Ranjan Das, Seong-Kyung Choi, Andreas Wiederkehr, Claes B. Wollheim, Seung-Kuy Cha, and Kyu-Sang Park Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; Nestlé Institute of Health Sciences, Lausanne, Switzerland, and Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
منابع مشابه
Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.
Inorganic phosphate (Pi) plays an important role in cell signaling and energy metabolism. In insulin-releasing cells, Pi transport into mitochondria is essential for the generation of ATP, a signaling factor in metabolism-secretion coupling. Elevated Pi concentrations, however, can have toxic effects in various cell types. The underlying molecular mechanisms are poorly understood. Here, we have...
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تاریخ انتشار 2015